MRI BIOPHYSICS GROUP

bridging the micro-macro gap with diffusion MRI

Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation.

TitleQuantifying brain microstructure with diffusion MRI: Theory and parameter estimation.
Publication TypeJournal Article
Year of Publication2018
AuthorsNovikov, DS, Fieremans, E, Jespersen, SN, Kiselev, VG
JournalNMR Biomed
Paginatione3998
Date PublishedOct
ISSN1099-1492 (Electronic); 0952-3480 (Linking)
Keywordsbrain, coarse-graining, Diffusion, mesoscopic transport, Microstructure, MRI
Abstract

We review, systematize and discuss models of diffusion in neuronal tissue, by putting them into an overarching physical context of coarse-graining over an increasing diffusion length scale. From this perspective, we view research on quantifying brain microstructure as occurring along three major avenues. The first avenue focusses on transient, or time-dependent, effects in diffusion. These effects signify the gradual coarse-graining of tissue structure, which occurs qualitatively differently in different brain tissue compartments. We show that transient effects contain information about the relevant length scales for neuronal tissue, such as the packing correlation length for neuronal fibers, as well as the degree of structural disorder along the neurites. The second avenue corresponds to the long-time limit, when the observed signal can be approximated as a sum of multiple nonexchanging anisotropic Gaussian components. Here, the challenge lies in parameter estimation and in resolving its hidden degeneracies. The third avenue employs multiple diffusion encoding techniques, able to access information not contained in the conventional diffusion propagator. We conclude with our outlook on future directions that could open exciting possibilities for designing quantitative markers of tissue physiology and pathology, based on methods of studying mesoscopic transport in disordered systems.

DOI10.1002/nbm.3998
PubMed ID30321478
Research Category: 

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