MRI BIOPHYSICS GROUP

bridging the micro-macro gap with diffusion MRI

White Matter Tract Integrity: An Indicator of Axonal Pathology after Mild Traumatic Brain Injury.

TitleWhite Matter Tract Integrity: An Indicator of Axonal Pathology after Mild Traumatic Brain Injury.
Publication TypeJournal Article
Year of Publication2018
AuthorsChung, S, Fieremans, E, Wang, X, Kucukboyaci, NE, Morton, CJ, Babb, J, Amorapanth, P, Foo, F-YA, Novikov, DS, Flanagan, SR, Rath, JF, Lui, YW
JournalJ Neurotrauma
Volume35
Pagination1015–1020
Date PublishedApr
ISSN1557-9042 (Electronic); 0897-7151 (Linking)
KeywordsDiffusion, kurtosis, mild traumatic brain injury, MRI, white matter tract integrity
Abstract

We seek to elucidate the underlying pathophysiology of injury sustained after mild traumatic brain injury (mTBI) using multi-shell diffusion magnetic resonance imaging, deriving compartment-specific white matter tract integrity (WMTI) metrics. WMTI allows a more biophysical interpretation of white matter (WM) changes by describing microstructural characteristics in both intra- and extra-axonal environments. Thirty-two patients with mTBI within 30 days of injury and 21 age- and sex-matched controls were imaged on a 3 Tesla magnetic resonance scanner. Multi-shell diffusion acquisition was performed with five b-values (250-2500 sec/mm(2)) along 6-60 diffusion encoding directions. Tract-based spatial statistics (TBSS) was used with family-wise error (FWE) correction for multiple comparisons. TBSS results demonstrated focally lower intra-axonal diffusivity (Daxon) in mTBI patients in the splenium of the corpus callosum (sCC; p < 0.05, FWE-corrected). The area under the curve value for Daxon was 0.76 with a low sensitivity of 46.9% but 100% specificity. These results indicate that Daxon may be a useful imaging biomarker highly specific for mTBI-related WM injury. The observed decrease in Daxon suggests restriction of the diffusion along the axons occurring shortly after injury.

DOI10.1089/neu.2017.5320
PubMed ID29239261
Research Category: 

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