bridging the micro-macro gap with diffusion MRI
I work on the experimental and theoretical development of translating the time-dependent diffusion coefficient as a clinical biomarker in tissues such as muscle and prostate. Due to physical and physiological constraints, conventional MRI techniques have spatial resolution that is limited to roughly 1 mm. Diffusion MRI is no exception to this; however, diffusion images derive their contrast from restrictions to water molecule diffusion can be 100-1000 times smaller than an MRI imaging voxel. Since Diffusion MRI is inherently sensitive to microscopic length scales and cellular architecture, I am using Diffusion MRI acquisition coupled with biophysical modeling to infer quantitative tissue parameters at the cellular level.