Clinical Translation

We work on quantifying neurodegeneration (demyelination and axonal loss) and inflammation in the brain; myofiber diameter and membrane permeability in muscle (to detect atrophy); and quantifying glandular lumen size and fraction, as well as size and permeability of stromal cells in the prostate (as promising markers for prostate cancer).

Publications

P. Kochunov, Donohue, B., Mitchell, B. D., Ganjgahi, H., Adhikari, B., Ryan, M., Medland, S. E., Jahanshad, N., Thompson, P. M., Blangero, J., Fieremans, E., Novikov, D. S., Marcus, D., Van Essen, D. C., Glahn, D. C., L. Hong, E., and Nichols, T. E., “Genomic kinship construction to enhance genetic analyses in the human connectome project data”, Human Brain Mapping, vol. 40, pp. 1677-1688, 2019.

S. Chung, Wang, X., Fieremans, E., Rath, J. F., Amorapanth, P., Foo, F. - Y. A., Morton, C. J., Novikov, D. S., Flanagan, S. R., and Lui, Y. W., “Altered Relationship between Working Memory and Brain Microstructure after Mild Traumatic Brain Injury.”, AJNR Am J Neuroradiol, vol. 40, no. 9, pp. 1438-1444, 2019.

S. Minaee, Wang, Y., Aygar, A., Chung, S., Wang, X., Lui, Y. W., Fieremans, E., Flanagan, S., and Rath, J., “MTBI Identification From Diffusion MR Images Using Bag of Adversarial Visual Features.”, IEEE Trans Med Imaging, 2019.

S. Chung, Fieremans, E., Kucukboyaci, N. E., Wang, X., Morton, C. J., Novikov, D. S., Rath, J. F., and Lui, Y. W., “Working Memory And Brain Tissue Microstructure: White Matter Tract Integrity Based On Multi-Shell Diffusion MRI”, vol. 8, no. 1, p. 3175, 2018.

S. Minaee, Wang, Y., Choromanska, A., Chung, S., Wang, X., Fieremans, E., Flanagan, S., Rath, J., and Lui, Y. W., “A Deep Unsupervised Learning Approach Toward MTBI Identification Using Diffusion MRI.”, Conf Proc IEEE Eng Med Biol Soc, vol. 2018, pp. 1267–1270, 2018.

B. M. Adhikari, Jahanshad, N., Shukla, D., Glahn, D. C., Blangero, J., Fox, P. T., Reynolds, R. C., Cox, R. W., Fieremans, E., Veraart, J., Novikov, D. S., Nichols, T. E., L Hong, E., Thompson, P. M., and Kochunov, P., “Comparison of heritability estimates on resting state fMRI connectivity phenotypes using the ENIGMA analysis pipeline.”, Hum Brain Mapp, vol. 39, pp. 4893–4902, 2018.

B. Ades-Aron, Yeager, S., Miskin, N., Fieremans, E., George, A., and Golomb, J., “Diffusional Kurtosis along the Corticospinal Tract in Adult Normal Pressure Hydrocephalus.”, AJNR Am J Neuroradiol, vol. 39, pp. 2218–2223, 2018.

B. M. Adhikari, Jahanshad, N., Shukla, D., Glahn, D. C., Blangero, J., Reynolds, R. C., Cox, R. W., Fieremans, E., Veraart, J., Novikov, D. S., Nichols, T. E., L Hong, E., Thompson, P. M., and Kochunov, P., “Heritability estimates on resting state fMRI data using ENIGMA analysis pipeline.”, Pac Symp Biocomput, vol. 23, pp. 307–318, 2018.

P. Kochunov, Dickie, E. W., Viviano, J. D., Turner, J., Kingsley, P. B., Jahanshad, N., Thompson, P. M., Ryan, M. C., Fieremans, E., Novikov, D. S., Veraart, J., Hong, E. L., Malhotra, A. K., Buchanan, R. W., Chavez, S., and Voineskos, A. N., “Integration of routine QA data into mega-analysis may improve quality and sensitivity of multisite diffusion tensor imaging studies.”, Hum Brain Mapp, vol. 39, pp. 1015–1023, 2018.

R. A. Sharma, Varga, A. W., Bubu, O. M., Pirraglia, E., Kam, K., Parekh, A., Wohlleber, M., Miller, M. D., Andrade, A., Lewis, C., Tweardy, S., Buj, M., Yau, P. L., Sadda, R., Mosconi, L., Li, Y., Butler, T., Glodzik, L., Fieremans, E., Babb, J. S., Blennow, K., Zetterberg, H., Lu, S. E., Badia, S. G., Romero, S., Rosenzweig, I., Gosselin, N., Jean-Louis, G., Rapoport, D. M., de Leon, M. J., Ayappa, I., and Osorio, R. S., “Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study.”, Am J Respir Crit Care Med, vol. 197, pp. 933–943, 2018.

S. Chung, Fieremans, E., Wang, X., Kucukboyaci, N. E., Morton, C. J., Babb, J., Amorapanth, P., Foo, F. - Y. A., Novikov, D. S., Flanagan, S. R., Rath, J. F., and Lui, Y. W., “White Matter Tract Integrity: An Indicator of Axonal Pathology after Mild Traumatic Brain Injury.”, J Neurotrauma, vol. 35, pp. 1015–1020, 2018.

E. Fieremans, Lemberskiy, G., Veraart, J., Sigmund, E. E., Gyftopoulos, S., and Novikov, D. S., “In vivo measurement of membrane permeability and myofiber size in human muscle using time-dependent diffusion tensor imaging and the random permeable barrier model.”, NMR Biomed, 2016.

P. Kochunov, Rowland, L. M., Fieremans, E., Veraart, J., Jahanshad, N., Eskandar, G., Du, X., Muellerklein, F., Savransky, A., Shukla, D., Sampath, H., Thompson, P. M., and L. Hong, E., “Diffusion-weighted imaging uncovers likely sources of processing-speed deficits in schizophrenia”, Proceedings of the National Academy of Sciences, vol. 113, pp. 13504-13509, 2016.

E. J. Grossman, Kirov, I. I., Gonen, O., Novikov, D. S., Davitz, M. S., Lui, Y. W., Grossman, R. I., Inglese, M., and Fieremans, E., “N-acetyl-aspartate levels correlate with intra-axonal compartment parameters from diffusion MRI”, Neuroimage, vol. 118, pp. 334-343, 2015.

I. O. Jelescu, Shepherd, T., Novikov, D. S., Ding, Y. - S., Koesters, T., Friedman, K., Galvin, J., and Fieremans, E., “Correlation of white matter damage with amyloid and hippocampal atrophy in normal aging and amnestic Mild Cognitive Impairment (aMCI): an MR-PET study.”, Journal of nuclear medicine, vol. 56, p. ?-?, 2015.

Y. Serulle, Pawar, R. V., Eubig, J., Fieremans, E., Kong, S. E., George, I. C., Morley, C., Babb, J. S., and George, A. E., “Diffusional Kurtosis Imaging in Hydrocephalus”, Magnetic resonance imaging, vol. 33, pp. 531-536, 2015.

I. O. Jelescu, Veraart, J., Adisetiyo, V., Milla, S., Novikov, D. S., and Fieremans, E., “One diffusion acquisition and different white matter models: How does microstructure change in human early development based on WMTI and NODDI?”, Neuroimage, vol. 107, pp. 242-256, 2014.

A. Paydar, Fieremans, E., Nwankwo, J. I., Lazar, M., Sheth, H. D., Adisetiyo, V., Helpern, J. A., Jensen, J. H., and Milla, S. S., “Diffusional kurtosis imaging of the developing brain”, AJNR. American journal of neuroradiology, vol. 35, pp. 808-814, 2014.

Y. Serulle, Rusinek, H., Kirov, I. I., Milch, H., Fieremans, E., Baxter, A. B., McMenamy, J., Jain, R., Wisoff, J., Golomb, J., Gonen, O., and George, A. E., “Differentiating shunt-responsive normal pressure hydrocephalus from Alzheimer disease and normal aging: pilot study using automated MRI brain tissue segmentation”, Journal of neurology, vol. 261, pp. 1994-2002, 2014.

E. E. Sigmund, Novikov, D. S., Sui, D., Ukpebor, O., Baete, S., Babb, J. S., Liu, K., Feiweier, T., Kwon, J., McGorty, K., Bencardino, J., and Fieremans, E., “Time-dependent diffusion in skeletal muscle with the random permeable barrier model (RPBM): application to normal controls and chronic exertional compartment syndrome patients”, NMR in biomedicine, vol. 27, pp. 519-528, 2014.

A. Benitez, Fieremans, E., Jensen, J. H., Falangola, M. F., Tabesh, A., Ferris, S. H., and Helpern, J. A., “White matter tract integrity metrics reflect the vulnerability of late-myelinating tracts in Alzheimer's disease”, NeuroImage: Clinical, vol. 4, pp. 64-71, 2013.

E. Fieremans, Benitez, A., Jensen, J. H., Falangola, M. F., Tabesh, A., Deardorff, R. L., Spampinato, M. V. S., Babb, J. S., Novikov, D. S., Ferris, S. H., and Helpern, J. A., “Novel White Matter Tract Integrity Metrics Sensitive to Alzheimer Disease Progression”, AJNR. American journal of neuroradiology, vol. 34, pp. 2105-2112, 2013.

E. J. Grossman, Jensen, J. H., Babb, J. S., Chen, Q., Tabesh, A., Fieremans, E., Xia, D., Inglese, M., and Grossman, R. I., “Cognitive impairment in mild traumatic brain injury: a longitudinal diffusional kurtosis and perfusion imaging study”, AJNR. American journal of neuroradiology, vol. 34, pp. 951-957, 2013.

E. E. Sigmund, Sui, D., Ukpebor, O., Baete, S., Fieremans, E., Babb, J. S., Mechlin, M., Liu, K., Kwon, J., McGorty, K., Hodnett, P. A., and Bencardino, J., “Stimulated echo diffusion tensor imaging and SPAIR T(2) -weighted imaging in chronic exertional compartment syndrome of the lower leg muscles”, Journal of magnetic resonance imaging, vol. 38, pp. 1073-1082, 2013.

E. S. Hui, Fieremans, E., Jensen, J. H., Tabesh, A., Feng, W., Bonilha, L., Spampinato, M. V., Adams, R., and Helpern, J. A., “Stroke assessment with diffusional kurtosis imaging”, Stroke, vol. 43, pp. 2968-2973, 2012.

D. S. Novikov, Fieremans, E., Jensen, J. H., and Helpern, J. A., “Random walk with barriers”, Nature physics, vol. 7, pp. 508-514, 2011.

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