bridging the micro-macro gap with diffusion MRI

Els Fieremans

Els Fieremans's picture

I am a faculty at the Department of RadiologyCenter for Biomedical Imaging, New York University School of Medicine, where I spearhead the MRI Biophysics group, together with Dr. Dmitry Novikov. I graduated Magna Cum Laude in Engineering in Physics from Ghent University in 2003, where I subsequently received my PhD in 2008 on Validation Methods for Diffusion Weighted Magnetic Resonance Imaging in Brain White Matter. I was a postdoctoral fellow at the Center for Biomedical Imaging, New York University School of Medicine during 2008-2011. Currently, my research focuses on early biomarkers for neurodegenerative diseases, novel contrasts from time-dependent diffusion MRI, and numerical simulations and design of MRI phantoms. 

Research Interests: 
  • Monte carlo simulations and physical phantoms
  • Biophysical modeling and subsequent animal validation
  • Design of imaging markers for white matter tract integrity describing axonal loss, demyelination and axonal injury from clinically usable diffusion protocols (e.g., diffusional kurtosis imaging) to assess neurodegenerative diseases including Alzheimer’s, multiple sclerosis, traumatic brain injury, cancer, as well as normal development
  • Multimodal imaging studies in Alzheimer’s pathology using MR-PET
  • Design of imaging markers from time-dependent diffusion in brain, muscular pathologies and prostate cancer
Selected Publications: 
  • Jelescu IO, Veraart J, Adisetiyo V, Milla SS, Novikov DS, Fieremans E. One diffusion acquisition and different white matter models: how does microstructure change in human early development based on WMTI and NODDI? Neuroimage 107, 242 (2015)
  • Novikov DS, Jensen JH, Helpern JA, Fieremans E. Revealing mesoscopic structural universality with diffusion. PNAS 111, 5088 (2014)
  • Novikov DS, Fieremans E, Jensen JH, Helpern JA. Random walks with barriers. Nature Physics 7, 508 (2011)
Awards and Honors: 
  • 2009: Henri Benedictus fellowship, Belgian American Foundation and King Baudouin Foundation
  • 2013: Junior Investigator of the Charleston Conference on Alzheimer’s Disease
  • 2014-2015: Fellow, Raymond and Beverly Sackler Laboratories for Convergence of Physical, Engineering and Biomedical Sciences in Honor of Saul J. Farber
  • 2003: Ph.D. Fellowship BOF (Special Research Fund), Ghent University, Belgium
  • 2003-2007: PhD. Fellowship IWT (Agency for Science through Innovation and Technology), Flanders, Belgium
  • 2009: Henri Benedictus postdoctoral fellowship, Belgian American Education and King Baudouin Foundation
  • 2011-2015: Alzheimer Drug Discovery Foundation
  • 2012-2015: NIH/NINDS R21 NS0812
  • 2012-2015: Sackler Fellowship
  • 2014-2015: Litwin Foundation for Alzheimer's Research
  • 2014-2019: NIH/NINDS R01 NS088040

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