WHO WE ARE

Our Scientists

ELS FIEREMANS

Associate Professor

I am a faculty at the Department of Radiology, Center for Biomedical Imaging, New York University School of Medicine, where I spearhead the MRI Biophysics group, together with Dr. Dmitry Novikov. I graduated Magna Cum Laude in Engineering in Physics from Ghent University in 2003, where I subsequently received my PhD in 2008 on Validation Methods for Diffusion Weighted Magnetic Resonance Imaging in Brain White Matter. I was a postdoctoral fellow at the Center for Biomedical Imaging, New York University School of Medicine during 2008-2011. Currently, my research focuses on early biomarkers for neurodegenerative diseases, novel contrasts from time-dependent diffusion MRI, and numerical simulations and design of MRI phantoms.

RESEARCH INTERESTS

  • Biophysical modeling and validation of diffusion models for tissue microstructure mapping
  • Numerical and physical phantoms for validation of microstructure mapping
  • Design of imaging markers for white matter tract integrity to assess neurodegenerative diseases
  • Design of imaging markers from time-dependent diffusion in brain white and gray matter, muscular pathologies and prostate cancer validation
  • Image processing and artifact correction methods for quantitative parameter estimation of diffusion MRI parameters
  • Multimodal imaging studies in Alzheimer’s pathology using MR-PET

SELECTED PUBLICATIONS

  • Lee HH, Papaioannou A, Kim SL, Novikov DS and Fieremans E. A time-dependent diffusion MRI signature of axon caliber variations and beading. (2020) Commun Biol. 3, 354 PubmedCommun BiolPMC Article
  • Dong JW, Jelescu IO, Ades-Aron B, Novikov DS, Friedman K, Babb JS, Osorio RS, Galvin JE, Shepherd TM and Fieremans E. Diffusion MRI biomarkers of white matter microstructure vary nonmonotonically with increasing cerebral amyloid deposition. (2020) Neurobiol Aging. 89, 118-128 PubmedNeurobiol AgingPMC Article
  • Novikov DS, Fieremans E, Jespersen SN and Kiselev VG. Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation. (2019) NMR Biomed. 32, e3998 PubmedNMR BiomedPMC Article
  • Fieremans E and Lee HH. Physical and numerical phantoms for the validation of brain microstructural MRI: A cookbook. (2018) Neuroimage. 182, 39-61 PubmedNeuroimagePMC Article
  • Ades-Aron B, Veraart J, Kochunov P, McGuire S, Sherman P, Kellner E, Novikov DS and Fieremans E. Evaluation of the accuracy and precision of the diffusion parameter EStImation with Gibbs and NoisE removal pipeline. (2018) Neuroimage. 183, 532-543 PubmedNeuroimagePMC Article
  • Fieremans E, Lemberskiy G, Veraart J, Sigmund EE, Gyftopoulos S and Novikov DS. In vivo measurement of membrane permeability and myofiber size in human muscle using time-dependent diffusion tensor imaging and the random permeable barrier model. (2017) NMR Biomed. 30, PubmedNMR Biomed
  • Lemberskiy G, Rosenkrantz AB, Veraart J, Taneja SS, Novikov DS and Fieremans E. Time-Dependent Diffusion in Prostate Cancer. (2017) Invest Radiol. 52, 405-411 PubmedInvest Radiol
  • Fieremans E, Jensen JH and Helpern JA. White matter characterization with diffusional kurtosis imaging. (2011) Neuroimage. 58, 177-88 PubmedNeuroimagePMC Article

AWARDS AND HONORS

  • 2009: Henri Benedictus fellowship, Belgian American Foundation and King Baudouin Foundation
  • 2013: Junior Investigator of the Charleston Conference on Alzheimer’s Disease
  • 2014-2015: Fellow, Raymond and Beverly Sackler Laboratories for Convergence of Physical, Engineering and Biomedical Sciences in Honor of Saul J. Farber
  • 2017: ISMRM Outstanding teacher Award
  • 2020: Hirschl-Weil-Caulier Career Scientist Award